反応 #444979

反応方程式

2-chloro-3-thiophenecarboxylic acid

→

5-bromo-2-chloro-3-thiophenecarboxylic acid

収率 77.5%

溶媒

acetic acid

反応条件

後処理

1. 1
   その他Precipitated crystals
2. 2
   ろ過were collected by filtration
3. 3
   workup.DISSOLUTIONdissolved in ethyl acetate
4. 4
   乾燥dried over anhydrous magnesium sulfate
5. 5
   濃縮The solution was concentrated under reduced pressure

実験手順

A mixture of 2-chloro-3-thiophenecarboxylic acid (2.44 g), pyridinium bromide perbromide (5.33 g) and acetic acid (15 ml) was stirred at 40° C. for 4 hours and poured into ice-water. Precipitated crystals were collected by filtration, dissolved in ethyl acetate and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure to give 5-bromo-2-chloro-3-thiophenecarboxylic acid (2.81 g) as crystals.

出典