反応 #44453

反応方程式

Cs2CO3

phenol

Water

1,4-dibromo-2-nitrobenzene

→

crude compound

収率 108.8%

4-Bromo-2-nitro-1-phenoxybenzene

収率 108.8%

溶媒

THF

ethyl acetate

反応条件

後処理

1. 1
   温度The resulting mixture was heated
2. 2
   温度to reflux
3. 3
   workup.STIRRINGstirred overnight
4. 4
   温度at reflux
5. 5
   抽出followed by extraction with ethyl acetate (3×)
6. 6
   洗浄The combined organic layers were washed with water and brine
7. 7
   乾燥dried (Na2SO4)
8. 8
   その他evaporated

実験手順

Cs2CO3 (4 g, 12.3 mmol) was added to a solution of phenol (1 g, 10.6 mmol) in 50 mL of THF under N2 atmosphere. After stirring for 15 min. 1,4-dibromo-2-nitrobenzene (2.81 g, 10 mmol) was added. The resulting mixture was heated to reflux and stirred overnight at reflux. Water and ethyl acetate were added, followed by extraction with ethyl acetate (3×). The combined organic layers were washed with water and brine, dried (Na2SO4) and evaporated to give the crude compound (3.2 g, 75%).

出典