反応 #4438

反応方程式

chloroform

4-(4-aminophenylamino)-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine

methanesulfonyl chloride

triethylamine

→

6-(3,4-dimethoxyphenyl)-4-(4-mesylaminophenylamino)-2-methylpyrimidine

溶媒

1,2-dichloroethane

反応条件

後処理

1. 1
   温度the mixture was refluxed for 3 hours
2. 2
   温度After cooled
3. 3
   洗浄washed with water
4. 4
   乾燥The solution was dried over magnesium sulfate
5. 5
   その他evaporated
6. 6
   その他chromatographed on silica gel eluting with chloroform

実験手順

To a solution of 4-(4-aminophenylamino)-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine (1.0 g) in 1,2-dichloroethane (20 ml) were added methanesulfonyl chloride (0.28 ml) and triethylamine (0.83 ml) and the mixture was refluxed for 3 hours. After cooled, chloroform (50 ml) was added thereto, and washed with water. The solution was dried over magnesium sulfate, evaporated, and chromatographed on silica gel eluting with chloroform to give 6-(3,4-dimethoxyphenyl)-4-(4-mesylaminophenylamino)-2-methylpyrimidine (0.45 g).

出典