反応 #44372

反応方程式

ethylbromoacetate

potassium carbonate

product

1-[(5′-chloro-3-fluoro-2′-hydroxy[1,1′-biphenyl]-4-yl)carbonyl]-pyrrolidine

Water

→

sub-title compound

[[5-chloro-3′-fluoro-4′-(1-pyrrolidinylcarbonyl)[1,1′-biphenyl]-2-yl]oxy]-acetic acid, ethyl ester

溶媒

DMF

ethyl acetate

反応条件

後処理

1. 1
   その他The organic layer was removed
2. 2
   乾燥dried (MgSO4)
3. 3
   その他evaporated in vacuo
4. 4
   その他The residue was purified by flash column chromatography
5. 5
   洗浄eluting with isohexane:ethyl acetate (1:1)

実験手順

The product of step c) (0.11 g) was dissolved in DMF (5 ml), ethylbromoacetate (0.04 ml) and potassium carbonate (0.1 g) were added. The reaction mixture was stirred for 16 h at RT. Water and ethyl acetate were added. The organic layer was removed, dried (MgSO4) and evaporated in vacuo. The residue was purified by flash column chromatography eluting with isohexane:ethyl acetate (1:1) to give the sub-title compound. Yield 0.12 g.

出典