反応 #44359

反応方程式

HCl

5-chloro-2-iodophenol

methyl bromoacetate

potassium carbonate

→

sub-title compound

Methyl (4-chloro-2-iodophenoxy)acetate

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 2 h
3. 3
   抽出the mixture was extracted with ether (three times)
4. 4
   乾燥The organic extracts were dried (MgSO4)
5. 5
   その他evaporated
6. 6
   その他purified by chromatography (silica, petrol ether as eluent)

実験手順

A mixture of 5-chloro-2-iodophenol (4.95 g), methyl bromoacetate (1.85 ml) and potassium carbonate (2.79 g) in acetonitrile (20 ml) was heated under reflux for 2 h. Aq HCl was added and the mixture was extracted with ether (three times). The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol ether as eluent) to give the sub-title compound (5.75 g).

出典