反応 #44346

反応方程式

sodium thiomethoxide

5-bromo-2-fluorobenzotrifluoride

water

→

sub-title compound

収率 68.3%

4-bromo-1-(methylthio)-2-(trifluoromethyl)-benzene

収率 68.3%

溶媒

DMF

反応条件

後処理

1. 1
   抽出extracted with isohexane
2. 2
   洗浄The organics were washed with brine
3. 3
   その他dried
4. 4
   濃縮concentrated in vacuo

実験手順

A mixture of sodium thiomethoxide (317 mg) and 5-bromo-2-fluorobenzotrifluoride (1.0 g) in DMF (4 ml) was heated at 50° C. for 1 h then poured into water and extracted with isohexane. The organics were washed with brine, dried and concentrated in vacuo to give the sub-title compound (762 mg).

出典