反応 #4434

反応方程式

3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)pyrimidine

sodium borohydride

→

6-(3,4-dimethoxyphenyl)-3-methyl-1,2,3,4-tetrahydro-4-(2,4,6-trimethylphenylimino)pyrimidine

収率 58.7%

溶媒

ethanol

water

反応条件

後処理

1. 1
   温度under reflux for 1.5 hours
2. 2
   その他After removal of the organic solvent
3. 3
   抽出extracted with ethyl acetate
4. 4
   乾燥The organic layer was dried over magnesium sulfate
5. 5
   その他evaporated
6. 6
   その他triturated in ethanol

実験手順

To a suspension of 3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)pyrimidine (2.0 g) in a mixture of ethanol (10 ml) and water (10 ml) was added sodium borohydride (1.04 g), and the mixture was stirred under reflux for 1.5 hours. After removal of the organic solvent, the mixture was suspended in water, and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, evaporated, and triturated in ethanol, to give 6-(3,4-dimethoxyphenyl)-3-methyl-1,2,3,4-tetrahydro-4-(2,4,6-trimethylphenylimino)pyrimidine (1.18 g).

出典