反応 #4433

反応方程式

2-chloro-3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)pyrimidine

1,2,3,6-tetrahydropyridine

→

3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-2-(1,2,3,6-tetrahydropyridin-1-yl)-4-(2,4,6-trimethylphenylimino)pyrimidine

溶媒

ethanol

反応条件

後処理

1. 1
   温度refluxed for 1.5 hours
2. 2
   その他The resulting precipitates
3. 3
   その他were collected
4. 4
   workup.DISSOLUTIONdissolved in chloroform
5. 5
   洗浄washed with aqueous sodium bicarbonate solution
6. 6
   乾燥dried over magnesium sulfate
7. 7
   その他After evaporated
8. 8
   その他the residue was triturated with diisopropyl ether

実験手順

To a suspension of 2-chloro-3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)pyrimidine (2.08 g) in ethanol (20 ml) was added 1,2,3,6-tetrahydropyridine (1.38 ml), and refluxed for 1.5 hours. The resulting precipitates were collected, dissolved in chloroform, washed with aqueous sodium bicarbonate solution, and dried over magnesium sulfate. After evaporated, the residue was triturated with diisopropyl ether to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-2-(1,2,3,6-tetrahydropyridin-1-yl)-4-(2,4,6-trimethylphenylimino)pyrimidine (1.95 g).

出典