反応 #44262

反応方程式

quinolin-6-ylmethanamine

3,5-dibromopyrazin-2-amine

di-isopropylethylamine

→

6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine

収率 49.0%

溶媒

dichloromethane ethanol

反応条件

後処理

1. 1
   ろ過the resulting suspension was filtered
2. 2
   洗浄The precipitate was washed sequentially with water and ether and air
3. 3
   その他dried

実験手順

A mixture of quinolin-6-ylmethanamine (13 g, 82 mmol), 3,5-dibromopyrazin-2-amine (21 g, 82 mmol) and di-isopropylethylamine (16 mL, 89 mmol) was heated to 130° C. for five hours. The reaction was diluted with dichloromethane:ethanol (9:1) and the resulting suspension was filtered. The precipitate was washed sequentially with water and ether and air dried to afford 6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine (13 g, 49%).

出典