反応 #442537

反応方程式

1,3-dichloropropane

6-bromo-2,3-dimethylhexanoic acid

isobutyric acid

→

title compound

5-chloro-2,3-dimethylpentanoic acid

反応条件

後処理

1. 1
   その他The product was purified by flash chromatography (CHCl3)

実験手順

The title compound was prepared as described for 6-bromo-2,3-dimethylhexanoic acid from isobutyric acid (9.67 g, 109.8 mmol), and 1,3-dichloropropane (37.2 g, 329.2 mmol). The product was purified by flash chromatography (CHCl3) to provide the acid (0.9 g, 5%) as a oil, HRMS (M+Li)+ calcd for C7H13O2ClLi 171.0764, found 171.0766.

出典