反応 #44153

反応方程式

3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

triethylamine

methanesulfonyl chloride

→

title compound

N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-N-(methylsulfonyl)methanesulfonamide

溶媒

DCM

反応条件

後処理

1. 1
   その他partitioned between saturated aqueous sodium hydrogencarbonate solution and DCM
2. 2
   洗浄The organic layer was washed with water
3. 3
   その他dried
4. 4
   濃縮concentrated in vacuo
5. 5
   その他The residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)]

実験手順

To a stirred solution of 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (370 mg) and triethylamine (178 μL) in DCM (3 mL) was added methanesulfonyl chloride (33 L). The mixture was stirred for 18 h, then partitioned between saturated aqueous sodium hydrogencarbonate solution and DCM. The organic layer was washed with water, dried and concentrated in vacuo. The residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)] to give the title compound (342 mg).

出典