反応 #44136

反応方程式

1,1,1-Tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3(1H)-one

3-[3-(2-hydroxyethyl)phenyl]-1,3-oxazolidin-2-one

→

title compound

収率 89.0%

[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]acetaldehyde

収率 89.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   洗浄washed with aqueous sodium hydroxide solution (1M, 10 mL)
2. 2
   乾燥The separated organic layer the latter was dried over magnesium sulfate
3. 3
   濃縮concentrated under reduced pressure

実験手順

1,1,1-Tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3(1H)-one (Dess-Martin periodinane, 709 mg, 1.67 mmol) was added to a solution of 3-[3-(2-hydroxyethyl)phenyl]-1,3-oxazolidin-2-one (315 mg, 1.52 mmol) in dichloromethane (10 mL). The mixture was stirred at room temperature for 30 min, then washed with aqueous sodium hydroxide solution (1M, 10 mL). The separated organic layer the latter was dried over magnesium sulfate and concentrated under reduced pressure affording the title compound in 89% yield (278 mg). The compound was used without further purification in the next step.

出典