反応 #44122

反応方程式

Trimethylsilyl chloride

(3-nitrophenyl)acetic acid

→

title compound

収率 100.0%

Methyl (3-nitrophenyl)acetate

収率 100.0%

溶媒

methanol

反応条件

後処理

1. 1
   濃縮concentrated at reduced pressure
2. 2
   その他partitioned between DCM and aqueous sodium hydrogencarbonate solution
3. 3
   乾燥The organic phase was dried over sodium sulfate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated under vacuum

実験手順

Trimethylsilyl chloride (5.6 mL, 2.0 equiv.) was added to a stirred solution of (3-nitrophenyl)acetic acid (4.0 g) in methanol (60 ml). The resulting solution was stirred at room temperature for 18 hours, then concentrated at reduced pressure and partitioned between DCM and aqueous sodium hydrogencarbonate solution. The organic phase was dried over sodium sulfate, filtered and concentrated under vacuum to give the title compound as a colourless liquid (4.2 g, 100%).

出典