反応 #440934

ord-748c19b58f914be88183d232a5126ad1

反応方程式

N#CN
cyanamide
CC(C)N1CCN(c2ccc(N=C=S)cc2)CC1
1-(4-isothio-cyanatophenyl)-4-isopropypiperazine
CC(C)N1CCN(c2ccc(N=C=S)cc2)CC1
1-(4-isothiocyanatophenyl)-4-(1-methylethyl)piperazine
N#Cc1cccc(C(=O)CBr)c1
3-cyanophenacyl bromide
→
CC(C)N1CCN(c2ccc(Nc3nc(N)c(C(=O)c4cccc(C#N)c4)s3)cc2)CC1
3-{4-Amino-2-[4-(4-isopropyl-piperazin-1-yl)-phenylamino]-thiazole-5-carbonyl}-benzonitrile

反応物

N#CN
cyanamide
CC(C)N1CCN(c2ccc(N=C=S)cc2)CC1
1-(4-isothio-cyanatophenyl)-4-isopropypiperazine
CC(C)N1CCN(c2ccc(N=C=S)cc2)CC1
1-(4-isothiocyanatophenyl)-4-(1-methylethyl)piperazine
N#Cc1cccc(C(=O)CBr)c1
3-cyanophenacyl bromide

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

This compound was prepared from cyanamide, 1-(4-isothio-cyanatophenyl)-4-isopropypiperazine (of Example 3) and 3-cyanophenacyl bromide (Maybridge Chemical Co. Ltd.) following the procedure used in Example 24. Mass spectrum (ES) MH+=447.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06756374B2uspto-grants-2004_06