反応 #440534

反応方程式

chlorotrimethysilane

Artemisinin

dextrose

Sodium borohydride

→

beta arteether

収率 72.8%

溶媒

ethanol

反応条件

後処理

1. 1
   workup.STIRRINGthe reaction mixture was further stirred for 1.5 hours at room temperature
2. 2
   その他After usual work up and purification through column chromatography (1:5 ratio)
3. 3
   workup.ADDITIONa mixture of alpha

実験手順

Artemisinin (1 g.) and polyhydroxy catalyst, dextrose (4 g.) were stirred in ethanol (15 ml). Sodium borohydride (500 mg.) was added slowly for 10 minutes and the reaction mixture was stirred for 30 minutes at room temperature (20-23° C.). After completion of the reduction step, chlorotrimethysilane (3.5 ml) was added and the reaction mixture was further stirred for 1.5 hours at room temperature. After usual work up and purification through column chromatography (1:5 ratio) a mixture of alpha and beta arteether (0.805 g., 80.5% w/w) were obtained.

出典