反応 #44044

ord-d6e25c829d9240aa83bcc02a7ca1062c

反応方程式

COC(OC)N(C)C
DMF-DMA
NN.O
hydrazine hydrate
CCC1CC(=O)CC(CC)N1S(=O)(=O)c1ccccn1
2,6-diethyl-1-(pyridin-2-ylsulfonyl)piperidin-4-one
CC[C@@H]1CC2(C[C@H](CC)N1)OCCO2
compound 126
CC[C@@H]1CC2(C[C@H](CC)N1)OCCO2
cis-7,9-diethyl-1,4-dioxa-8-azaspiro[4.5]decane
Cl.O=S(=O)(Cl)c1ccccn1
pyridine-2-sulfonyl chloride hydrochloride
c1cn[nH]c1
pyrazole
→
CC[C@@H]1Cc2[nH]ncc2[C@H](CC)N1S(=O)(=O)c1ccccn1
cis-4,6-Diethyl-5-(pyridin-2-ylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

反応物

COC(OC)N(C)C
DMF-DMA
NN.O
hydrazine hydrate
CCC1CC(=O)CC(CC)N1S(=O)(=O)c1ccccn1
2,6-diethyl-1-(pyridin-2-ylsulfonyl)piperidin-4-one
CC[C@@H]1CC2(C[C@H](CC)N1)OCCO2
compound 126
CC[C@@H]1CC2(C[C@H](CC)N1)OCCO2
cis-7,9-diethyl-1,4-dioxa-8-azaspiro[4.5]decane
Cl.O=S(=O)(Cl)c1ccccn1
pyridine-2-sulfonyl chloride hydrochloride
c1cn[nH]c1
pyrazole

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Prepared by treatment of 2,6-diethyl-1-(pyridin-2-ylsulfonyl)piperidin-4-one, which was prepared by sulfonylation of compound 126 using pyridine-2-sulfonyl chloride hydrochloride followed by deprotection as shown in Example 17, with DMF-DMA followed by pyrazole formation using hydrazine hydrate as shown in Example 15,

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07732609B2uspto-grants-2010_06