反応 #43923

反応方程式

ethyl 4-chloroacetoacetate

resorcinol

→

title compound

収率 84.0%

4-(chloromethyl)-7-hydroxy-2H-chromen-2-one

収率 84.0%

溶媒

sulfuric acid

反応条件

後処理

1. 1
   温度Under ice-cooling
2. 2
   ろ過the precipitated solid was collected by filtration
3. 3
   洗浄washed with water
4. 4
   その他air-dried

実験手順

Under ice-cooling, ethyl 4-chloroacetoacetate (14.0 g, 85.0 mmol) was dissolved in concentrated sulfuric acid (30 mL), resorcinol (8.81 g, 80.0 mmol) was added by small portions, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was poured into ice water, and the precipitated solid was collected by filtration, washed with water, and air-dried to give the title compound (14.1 g, yield 84%) as a beige powder.

出典