反応 #4389

反応方程式

2-Amino-3-chloropyrazine

2-methylbenzyl alcohol

sodium hydride

→

2-amino-3-(2-methylbenzyloxy)pyrazine

収率 41.5%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   workup.ADDITIONpoured
2. 2
   その他onto crushed ice
3. 3
   その他The resulting precipitates
4. 4
   ろ過were collected by filtration
5. 5
   洗浄washed with n-hexane
6. 6
   その他dried in a desiccator

実験手順

To a solution of 2-methylbenzyl alcohol (0.985 g) in N,N-dimethylformamide (10 ml) was added 62.8% sodium hydride (0.308 g) under a nitrogen atmosphere and then stirred for 30 minutes. 2-Amino-3-chloropyrazine (0.87 g) was added to the solution and the mixture was heated at 65° C. for 2 hours and poured onto crushed ice. The resulting precipitates were collected by filtration, washed with n-hexane, and dried in a desiccator to give 2-amino-3-(2-methylbenzyloxy)pyrazine (0.6 g).

出典