反応 #43885

反応方程式

Tartaric acid

oseltamivir

→

oseltamivir tartrate

収率 97.6%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   温度slowly cooled to 30° C. in 1 hour
2. 2
   ろ過Filtered the solid
3. 3
   洗浄washed with 70 ml of ethyl acetate
4. 4
   その他dried

実験手順

Tartaric acid (5 gm) is added to the solution of oseltamivir free base (9 gm, HPLC purity: 95.8%) in ethyl acetate (50 ml) at 25-30° C., the contents are heated to 50° C. and then slowly cooled to 30° C. in 1 hour. Filtered the solid, washed with 70 ml of ethyl acetate and dried to yield 13 gm of oseltamivir tartrate (HPLC purity: 97.2%).

出典