反応 #43876

反応方程式

3,4-Difluoro-benzoyl chloride

(5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

DIEA

→

subtitle compound

{5-[Benzyl-(3,4-difluoro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

溶媒

HCl

CH2Cl2

反応条件

後処理

1. 1
   ろ過filtered through an Extrelut column
2. 2
   洗浄The Extrelut column was washed with CH2Cl2
3. 3
   濃縮the filtrate was concentrated

実験手順

3,4-Difluoro-benzoyl chloride (45 μL, 0.36 mmol) was added to a solution of (5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester (45 mg, 0.12 mmol), DIEA (41 μL, 0.24 mmol) and DMAP (15 mg, 0.12 mmol) in CH2Cl2 (1 mL), and stirred overnight at room temperature. The reaction solution was diluted with aqueous HCl (1.0 M) and filtered through an Extrelut column. The Extrelut column was washed with CH2Cl2, and the filtrate was concentrated to afford the subtitle compound that was used without further purification. MS calculated for C30H31F2N3O3+H: 520, observed: 520.

出典