反応 #43820

反応方程式

2-Chlorobenzyl chloride

K2CO3

[5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

→

{5-[(2-Chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

溶媒

EtOAc

H2O

CH3CN

反応条件

後処理

1. 1
   ろ過filtered through an Extrelut column
2. 2
   洗浄The column was washed with EtOAc
3. 3
   濃縮the filtrate was concentrated
4. 4
   その他The crude product was carried onto the next reaction without any further purification or characterization

実験手順

2-Chlorobenzyl chloride (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

出典