反応 #43814

反応方程式

3-Nitro-benzene-1,2-diamine

butyraldehyde

NH4OH

→

sub-title compound

収率 87.2%

4-Nitro-2-propyl-1H-benzoimidazole

収率 87.2%

溶媒

POCl3

反応条件

後処理

1. 1
   workup.ADDITIONpoured over ice
2. 2
   ろ過The precipitate was filtered
3. 3
   洗浄washed with ice water

実験手順

3-Nitro-benzene-1,2-diamine (1.0 g, 6.54 mmol) and butyraldehyde (630 μL, 7.19 mmol) were stirred in POCl3 (10 mL) at 85° C. for 3 hours. The reaction was cooled to ambient temperature and poured over ice. The resulting mixture was basified with NH4OH. The precipitate was filtered and washed with ice water to give 1.17 g of the sub-title compound that was used without further purification.

出典