反応 #43811

反応方程式

product

(5-tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

NaOH

→

title compound

(5 -tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid

溶媒

DCM

ethanol

反応条件

後処理

1. 1
   抽出extracted with water
2. 2
   抽出extracted with DCM
3. 3
   洗浄The organic layer was washed with water
4. 4
   濃縮concentrated
5. 5
   その他purified by preparative LCMS

実験手順

The product of step d.) was dissolved in 3 mL ethanol, treated with 1 M NaOH (500 μL), and heated to 70° C. for one hour. The reaction was diluted in DCM and extracted with water. The aqueous layer was acidified with 1 M HCl and extracted with DCM. The organic layer was washed with water, concentrated and purified by preparative LCMS to give the title compound. MS: ESI (positive): 334 (M+H).

出典