反応 #437855

反応方程式

dibutyltin dilaurate

(R)-mandelic acid

4-chlorophenyl isocyanate

water

→

(R)-(4-chlorophenylcarbamoyloxy)phenylacetic acid

溶媒

dichloromethane

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate
2. 2
   その他The organic phase is evaporated

実験手順

1.1 400 mg (0.63 mmol) of dibutyltin dilaurate are added to a solution of 10.0 g (65.7 mmol) of (R)-mandelic acid and 10.0 g (65.1 mmol) of 4-chlorophenyl isocyanate in 100 ml of dichloromethane, and the mixture is stirred at room temperature for 24 hours. The reaction mixture is introduced into water and extracted with ethyl acetate. The organic phase is evaporated, giving (R)-(4-chlorophenylcarbamoyloxy)phenylacetic acid as a colourless solid; ESI 306.

出典