反応 #437798

反応方程式

HCl

2-cyano-acetanilide

tri-n-butyltin azide

→

2-(1H-tetrazol-5-yl)acetanilide

収率 90.3%

溶媒

Et2O

toluene

反応条件

後処理

1. 1
   温度at reflux for 48 hrs
2. 2
   その他The resulting precipate was collected by suction
3. 3
   洗浄washed with hexane
4. 4
   その他dried in vacuo

実験手順

A solution of 2-cyano-acetanilide (0.801 g, 5.0 mmol) and tri-n-butyltin azide (2.05 mL, 7.5 mmol) in anhydrous toluene (10 mL) was heated at reflux for 48 hrs. The mixture was allowed to cool to room temperature and treated with 2.0 N HCl in Et2O (5.0 mL). The resulting precipate was collected by suction, washed with hexane and dried in vacuo to give 2-(1H-tetrazol-5-yl)acetanilide (0.917 g, 90%) as a white solid.

出典