反応 #4377

反応方程式

iodine

1-(3-methoxyphenyl)butane-3-one

→

1-(2-iodo-5-methoxyphenyl)butane-3-one

収率 82.3%

溶媒

acetic acid

反応条件

後処理

1. 1
   その他The silver iodide was removed by filtration
2. 2
   洗浄washed with acetic acid
3. 3
   その他The filtrate was partitioned between ether and water
4. 4
   洗浄The ether layer was washed with water, sodium bicarbonate solution and sodium thiosulfate solution
5. 5
   乾燥The ether solution was dried with MgSO4
6. 6
   その他evaporated to dryness in vacuo

実験手順

Samples of iodine (42.4 g, 0.167 mole) and silver acetate (27.87 g, 0.167 mole) were added in portions to a solution of 29.8 g (0.167 mole) of 1-(3-methoxyphenyl)butane-3-one in 167 ml of glacial acetic acid. The mixture was stirred one hour. The silver iodide was removed by filtration and washed with acetic acid. The filtrate was partitioned between ether and water. The ether layer was washed with water, sodium bicarbonate solution and sodium thiosulfate solution. The ether solution was dried with MgSO4 and evaporated to dryness in vacuo. There was obtained 41.8 g (82% yield) of oily 1-(2-iodo-5-methoxyphenyl)butane-3-one.

出典