反応 #4376
ord-06fbe5b3f1e34d95a302135ea4df5b48
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1その他the solid collected
- 2その他It was recrystallized from toluene
実験手順
A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).