反応 #43759

反応方程式

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-chloro-6-nitro-1-benzothiophene-2-carboxamide hydrochloride

→

title compound

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-3-chloro-6-amino-1-benzothiophene-2-carboxamide dihydrochloride

溶媒

tin(II) chloride

DMF

反応条件

後処理

1. 1
   その他The reaction mixture is purified by preparative HPLC
2. 2
   濃縮The product fractions are concentrated
3. 3
   workup.DISSOLUTIONdissolved in a mixture of methanol and 4M HCl in dioxane
4. 4
   濃縮again concentrated
5. 5
   その他dried under high vacuum

実験手順

83 mg (0.23 mmol) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-chloro-6-nitro-1-benzothiophene-2-carboxamide hydrochloride are dissolved in 1.5 ml of 2M tin(II) chloride solution in DMF and stirred at RT for 14 h. The reaction mixture is purified by preparative HPLC. The product fractions are concentrated, dissolved in a mixture of methanol and 4M HCl in dioxane, then again concentrated and dried under high vacuum. 53 mg (57.2% of theory) of the title compound are obtained.

出典