反応 #43692

反応方程式

4-(7-methyl-6-oxo-5,6,7,8-tetrahydro-imidazol[1,5-a]pyrazin-5-yl)-benzonitrile

Et2O—HCl

→

title compound

4-(7-Methyl-6-oxo-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazin-5-yl)-benzonitrile hydrochloride

溶媒

acetone

反応条件

後処理

1. 1
   その他obtained analogously to Example 1

実験手順

The title compound is prepared analogously to Example 1, i.e., 4-(7-methyl-6-oxo-5,6,7,8-tetrahydro-imidazol[1,5-a]pyrazin-5-yl)-benzonitrile, obtained analogously to Example 1, is dissolved in acetone, then treated with Et2O—HCl(g) to afford the hydrochloride salt: m.p. 222-224° C.; 1H-NMR (DMSO-d6) 9.07 (1H, s), 7.92 (2H, d, J=8.2), 7.48 (1H, s), 7.49 (2H, d, J=8.2), 6.46 (1H, s), 4.83 (2H, s), 3.03 (3H, s); 13C-NMR (DMSO-d6) δ 162.5, 140.5, 134.3, 133.4, 128.7, 125.1, 118.6, 115.7, 112.4, 60.9, 43.1, 34.9; e/z (ES) 253 (M+1, 100%); calculated for C14H12N4O HCl 0.4H2O, C, 56.82; H, 4.70; N, 18.93. found C, 56.88; H, 4.54; N, 18.89.

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