反応 #43666

反応方程式

Clopidogrel

benzene sulphonic acid

→

Clopidogrel besylate

溶媒

diethyl ether

diethyl ether

反応条件

後処理

1. 1
   ろ過The white solid was collected by filtration
2. 2
   洗浄washed with diethyl ether
3. 3
   その他dried at 50-60° C. in a vacuum oven

実験手順

Clopidogrel base was dissolved in diethyl ether at 20-25° C. To this was added benzene sulphonic acid dissolved in diethyl ether. The reaction mixture was stirred at 25-30° C. for 24-30 hrs. The white solid was collected by filtration, washed with diethyl ether, and dried at 50-60° C. in a vacuum oven to obtain Clopidogrel besylate crystalline form.

出典