反応 #43665

反応方程式

Clopidogrel

Benzene sulphonic acid

toluene

→

Clopidogrel besylate

溶媒

methanol

反応条件

後処理

1. 1
   温度The reaction mixture was heated
2. 2
   温度to reflux temperature for 2 hrs
3. 3
   温度The resulting solution was refluxed for an additional 20 minutes
4. 4
   温度The solution was cooled to room temperature
5. 5
   その他The solvent was evaporated under reduced pressure to dryness

実験手順

Clopidogrel base was dissolved in methanol. Benzene sulphonic acid was added to the solution at 20° C. The reaction mixture was heated to reflux temperature for 2 hrs. The solution was cooled to room temperature and the methanolic solution was added drop-wise to the boiling toluene. The resulting solution was refluxed for an additional 20 minutes. The solution was cooled to room temperature and was stirred at this temperature for extended hours. The solvent was evaporated under reduced pressure to dryness to obtain Clopidogrel besylate, similar to that obtained above.

出典