反応 #43664

反応方程式

Clopidogrel

Benzene sulphonic acid

diethyl ether

→

Clopidogrel besylate

溶媒

methanol

反応条件

後処理

1. 1
   温度The reaction mixture was heated
2. 2
   温度to reflux temperature for 2 hrs
3. 3
   ろ過The solid was filtered
4. 4
   その他dried in a vacuum oven

実験手順

Clopidogrel base was dissolved in methanol. Benzene sulphonic acid was added to the solution at 20° C. The reaction mixture was heated to reflux temperature for 2 hrs. The solution was cooled to room temperature and was added drop-wise to diethyl ether. The suspension was stirred at RT. The solid was filtered and dried in a vacuum oven to give Clopidogrel besylate, similar to that obtained above.

出典