反応 #43642

反応方程式

1,1-dimethylethyl[(3R,4S)-3-(methyloxy)-4-piperidinyl]carbamate

methyl 2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]-2-propenoate

→

desired product

収率 142.8%

Methyl 3-[(3R,4S)-4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(methyloxy)-1-piperidinyl]-2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]propanoate

収率 142.8%

反応条件

後処理

1. 1
   その他The title compound was prepared

実験手順

The title compound was prepared according to the general method of Example 2(d) from 1,1-dimethylethyl[(3R,4S)-3-(methyloxy)-4-piperidinyl]carbamate (1.29 g, 5.63 mmol) and methyl 2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]-2-propenoate (1.48 g, 5.63 mmol) to give the desired product (1.98 g, 71%).

出典