反応 #43630

反応方程式

7-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2,3-dihydro-5(1H)-indolizinone

acetic acid

tetrabutylammonium fluoride

→

desired product

収率 80.3%

7-(hydroxymethyl)-2,3-dihydro-5(1H)-indolizinone

収率 80.3%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他before being evaporated
2. 2
   その他The residue was chromatographed on silica eluting with 0-20% methanol in dichloromethane

実験手順

A solution of 7-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2,3-dihydro-5(1H)-indolizinone (3.93 g, 14.09 mmol) in tetrahydrofuran (100 ml) was treated with acetic acid (1.61 ml, 28.17 mmol) and tetrabutylammonium fluoride (1M in THF, 21 ml, 21.13 mmol) and stirred at room temperature for 1 h before being evaporated. The residue was chromatographed on silica eluting with 0-20% methanol in dichloromethane to give the desired product (1.87 g, 80%)

出典