反応 #435945

反応方程式

ammonium chloride

THF

compound

5-bromo-2-[4-(t-butyldiphenylsilyloxy)butyl]indan-1-one

sodium borohydride

→

compound

収率 75.6%

5-bromo-2-[4-(t-butyldiphenylsilyloxy)butyl]indan-1-ol

収率 75.6%

溶媒

methanol

反応条件

後処理

1. 1
   抽出subjected to separation/extraction with chloroform
2. 2
   乾燥The organic layer was dried with anhydrous sodium sulfate
3. 3
   濃縮concentrated under reduced pressure
4. 4
   その他The residue was purified through silica gel column chromatography (hexane/ethyl acetate)

実験手順

The compound (2.03 g) obtained in Example 127-4 was dissolved in methanol (60.9 ml) and THF (30.5 ml) and, under ice-cooling, added with sodium borohydride (0.442 g), followed by stirring at room temperature for 2 hours. The reaction solution was added with a saturated aqueous ammonium chloride solution and then subjected to separation/extraction with chloroform. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (hexane/ethyl acetate), thereby obtaining the subject compound (1.54 g) as a yellow oily substance.

出典