反応 #435644

反応方程式

methanol

[5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid

cyclobutanemethanol

→

titled compound

収率 92.0%

[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid cyclobutylmethyl ester

収率 92.0%

溶媒

dichloromethane

反応条件

実験手順

The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using cyclobutanemethanol (32 μL, 0.34 mmol) as the coupling partner. Chromatography (1:1 methanol:dichloromethane) through SiO2 yielded 56 mg (92%) of the titled compound. ESI-MS m/z 360 (MH+), 358 (M−H−).

出典