反応 #43537

反応方程式

(S)-2-(benzylcarbonylamino)-propanol

Dess-Martin periodinane

→

(S)-2-(benzylcarbonylamino)-propionaldehyde

溶媒

CH2Cl2

反応条件

後処理

1. 1
   その他quenched with sodium thiosulphate
2. 2
   その他the solvent removed in vacuo
3. 3
   その他The residue was then separated between sodium hydroxide (1M, 500 mL) and ethyl acetate (500 mL)
4. 4
   洗浄The organics were washed with brine
5. 5
   乾燥dried (MgSO4)
6. 6
   その他evaporated in vacuo
7. 7
   その他to yield a clear oil which
8. 8
   その他was used immediately in the next step without further purification

実験手順

(S)-2-(benzylcarbonylamino)-propanol (5 g, 23.9 mmol) was dissolved in CH2Cl2 (200 mL) and treated with Dess-Martin periodinane (12.26 g, 1.1 eq). The mixture was stirred for 2 hours, then quenched with sodium thiosulphate, and the solvent removed in vacuo. The residue was then separated between sodium hydroxide (1M, 500 mL) and ethyl acetate (500 mL). The organics were washed with brine, dried (MgSO4) and evaporated in vacuo to yield a clear oil which was used immediately in the next step without further purification.

出典