反応 #43458

反応方程式

3-ethenyl-5,6-dihydrofuro[2,3-c]pyridazine

sodium periodate

1,4-dioxane

→

product

収率 20.7%

5,6-Dihydrofuro[2,3-c]pyridazine-3-carbaldehyde

収率 20.7%

溶媒

water

water

反応条件

後処理

1. 1
   その他The mixture was evaporated
2. 2
   workup.ADDITIONthe residue treated with chloroform
3. 3
   workup.ADDITIONadded to the top of a column
4. 4
   洗浄Elution with ethyl acetate

実験手順

A mixture of 3-ethenyl-5,6-dihydrofuro[2,3-c]pyridazine (110 mg, 0.74 mmol), 4% osmium tetroxide in water (0.66 ml), sodium periodate (367 mg), 1,4-dioxane (6.6 ml) and water (1.3 ml) was stirred for 3 hours. The mixture was evaporated and the residue treated with chloroform and added to the top of a column. Elution with ethyl acetate afforded the product (23 mg).

出典