反応 #43451

反応方程式

2,3-dihydro-1-benzofuran-5-carbaldehyde

sodium acetate

bromine

→

desired compound

収率 91.3%

7-bromo-2,3-dihydro-1-benzofuran-5-carbaldehyde

収率 91.3%

溶媒

acetic acid

sodium thiosulfate

反応条件

後処理

1. 1
   洗浄washed with a saturated aqueous solution of sodium bicarbonate
2. 2
   抽出extracted with ethyl acetate
3. 3
   乾燥dried over sodium sulfate
4. 4
   その他dried in vacuo

実験手順

To a solution of 2,3-dihydro-1-benzofuran-5-carbaldehyde (1.0 g, 6.75 mmol) in glacial acetic acid (8 ml) was added sodium acetate (664 mg, 8.1 mmol) and bromine (0.7 ml, 13.5 mmol) at 10° C. slowly. The reaction was stirred for 2 h at room temperature. The reaction was diluted with a saturated aqueous solution of sodium thiosulfate (10 ml), washed with a saturated aqueous solution of sodium bicarbonate, and then extracted with ethyl acetate. Organics were combined, dried over sodium sulfate and dried in vacuo to give the desired compound (1.4 g, 91%).

出典