反応 #43446

反応方程式

bromomaleic anhydride

Hydrazine sulphate salt

bromomaleic anhydride

hydrazine sulphate

→

4-bromo-1,2-dihydro-3,6-pyridazinedione

収率 151.0%

溶媒

water

water

反応条件

後処理

1. 1
   温度heated
2. 2
   温度to reflux
3. 3
   温度The mixture was heated
4. 4
   温度at reflux for 4 hours
5. 5
   ろ過The precipitates were collected by filtration
6. 6
   洗浄washed with water and acetone
7. 7
   その他dried as a combined batch in vacuo

実験手順

Hydrazine sulphate salt (51 g) was suspended in water (250 ml), heated to reflux and bromomaleic anhydride (90.38 g) was added dropwise. The mixture was heated at reflux for 4 hours then cooled to room temperature. The reaction was repeated with 29 g hydrazine sulphate, 53 g bromomaleic anhydride and 130 ml water. The precipitates were collected by filtration, washed with water and acetone and dried as a combined batch in vacuo to afford 4-bromo-1,2-dihydro-3,6-pyridazinedione as a white solid (113 g).

出典