反応 #43436

反応方程式

{5-({[4-(methyloxy)phenyl]methyl}oxy)-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate

triethylsilane

trifluoroacetic acid

→

{5-Hydroxy-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate trifluoroacetate salt

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他After 16 hours the mixture was evaporated
2. 2
   その他triturated with toluene/ethyl acetate (250 ml/5 ml)
3. 3
   その他affording a white solid
4. 4
   その他that was isolated by filtration
5. 5
   その他dried in vacuo (22.5 g)

実験手順

A solution of {5-({[4-(methyloxy)phenyl]methyl}oxy)-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate (26.3 g, 67 mmol) in dichloromethane (700 ml) was treated with triethylsilane (10 ml, 62.6 mmol)and trifluoroacetic acid (35 ml). After 16 hours the mixture was evaporated and triturated with toluene/ethyl acetate (250 ml/5 ml) affording a white solid that was isolated by filtration and dried in vacuo (22.5 g).

出典