反応 #433859
ord-b672429898944e23b01a2d853ad34746
反応方程式
6-bromonaphthalene-2-thiol
4-fluoro-2-trifluoromethyl benzonitrile
triethylamine
→
4-(6-bromonaphth-2-ylthio)-2-trifluoromethylbenzonitrile
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1洗浄washed with water (3×25 ml) and brine (25 ml)
- 2乾燥dried (MgSO4)
- 3その他evaporated
- 4その他to give a yellow oil
- 5その他Crystallisation from methanol (20 ml)
実験手順
A mixture of 6-bromonaphthalene-2-thiol (956 mg) and 4-fluoro-2-trifluoromethyl benzonitrile (756 mg) in dimethylformamide (15 ml), at ambient temperature, was treated dropwise with triethylamine (504 mg). After stirring at ambient temperature for 3 hours the reaction mixture was diluted with ethyl acetate (100 ml), washed with water (3×25 ml) and brine (25 ml), dried (MgSO4) and evaporated to give a yellow oil. Crystallisation from methanol (20 ml) gave 4-(6-bromonaphth-2-ylthio)-2-trifluoromethylbenzonitrile (1.176 g, mp 114-116° C.;