反応 #43362

ord-e1f2d77202414f3fbb071e9583ee6a02

反応方程式

O=c1cccc[nH]1
1H-pyridin-2-one
CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(-n2ccc(OCc3ccc(Cl)cn3)cc2=O)cc1
4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(2R)-1-(tert-butoxycarbonyl)-2-pyrrolidinyl]methyloxy}phenyl)-1H-pyridin-2-one
→
O=c1cc(OCc2ccc(Cl)cn2)ccn1-c1ccc(OC[C@H]2CCCN2)cc1
title compound
O=c1cc(OCc2ccc(Cl)cn2)ccn1-c1ccc(OC[C@H]2CCCN2)cc1
4-[(5-Chloro-2-pyridinyl)methoxy]-1-(4-{[(2R)-2-pyrrolidinyl]methoxy}phenyl)-1H-pyridin-2-one

反応物

O=c1cccc[nH]1
1H-pyridin-2-one
CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(-n2ccc(OCc3ccc(Cl)cn3)cc2=O)cc1
4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(2R)-1-(tert-butoxycarbonyl)-2-pyrrolidinyl]methyloxy}phenyl)-1H-pyridin-2-one

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Example 121 was repeated except that 4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(3R)-1-tert-butoxycarbonyl)-3-pyrrolidinyl]oxy}phenyl)-1H-pyridin-2-one was replaced with 4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(2R)-1-(tert-butoxycarbonyl)-2-pyrrolidinyl]methyloxy}phenyl)-1H-pyridin-2-one to provide the title compound.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07732456B2uspto-grants-2010_06