反応 #43356

反応方程式

( 3 )

4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{2-[(3S)-3-hydroxy-1-pyrrolidinyl]ethoxy}phenyl)-1H-pyridin-2-one

tert-butyl (2S)-2-(fluoromethyl)pyrrolidine-1-carboxylate

tert-butyl (3R)-3-(2-fluoroethoxy)pyrrolidine-1-carboxylate

→

title compound

2-[(3R)-3-(2-fluoroethoxy)-1-pyrrolidinyl]ethanol

反応条件

実験手順

Steps (2) and (3) of Example 89 were repeated except that tert-butyl (2S)-2-(fluoromethyl)pyrrolidine-1-carboxylate used in the Step (2) was replaced with tert-butyl (3R)-3-(2-fluoroethoxy)pyrrolidine-1-carboxylate, to provide the title compound.

出典