反応 #43333

反応方程式

Potassium carbonate

methyl p-toluenesulfonate

DMF

1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one

→

title compound

収率 53.0%

4-[(E)-2-(4-methoxyphenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl]-ethoxy}phenyl)-1H-pyridin-2-one

収率 53.0%

溶媒

Ethyl acetate

反応条件

後処理

1. 1
   洗浄by washing with water and saturated brine
2. 2
   乾燥drying over anhydrous sodium sulfate
3. 3
   濃縮Concentrating
4. 4
   その他the reaction liquid under reduced pressure
5. 5
   その他the residue was purified on silica gel column chromatography (C-300; methanol:chloroform=1:20-1:10)

実験手順

Potassium carbonate (11 mg, 0.08 mmol) and methyl p-toluenesulfonate (6 mg, 0.03 mmol) were added to DMF (2 mL) solution of 4-[(E)-2-4-hydroxyphenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one (11 mg, 0.03 mmol), and stirred for a day and night at 80° C. Ethyl acetate was added to the reaction liquid, followed by washing with water and saturated brine and drying over anhydrous sodium sulfate. Concentrating the reaction liquid under reduced pressure, the residue was purified on silica gel column chromatography (C-300; methanol:chloroform=1:20-1:10) to provide the title compound (6 mg, 53%) as a white solid.

出典