反応 #43332

反応方程式

Trifluoroacetic acid

4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one

→

title compound

収率 92.7%

4-[(E)-2-(4-hydroxyphenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl)-ethoxy]phenyl}-1H-pyridin-2-one

収率 92.7%

反応条件

後処理

1. 1
   濃縮After concentrating
2. 2
   その他the reaction liquid under reduced pressure, chloroform
3. 3
   workup.ADDITIONwas added to the reaction liquid which
4. 4
   洗浄then was washed with aqueous sodium hydrogencarbonate solution
5. 5
   乾燥dried over anhydrous sodium sulfate
6. 6
   濃縮Concentrating the solvent under reduced pressure

実験手順

Trifluoroacetic acid (2 mL) was added to 4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one (120 mg, 0.26 mmol) and stirred at room temperature for 30 minutes. After concentrating the reaction liquid under reduced pressure, chloroform was added to the reaction liquid which then was washed with aqueous sodium hydrogencarbonate solution and dried over anhydrous sodium sulfate. Concentrating the solvent under reduced pressure, the title compound (97 mg, 92%) was obtained as a white solid.

出典