反応 #43328

反応方程式

4-Fluorostyrene

potassium carbonate

DMF

4-iodo-2-(4-methoxybenzyloxy)pyridine

→

title compound

収率 61.0%

4-[(E)-2-(4-fluorophenyl)vinyl]-2-(4-methoxybenzyloxy)-pyridine

収率 61.0%

溶媒

brine

反応条件

後処理

1. 1
   抽出followed by extraction with ethyl acetate
2. 2
   乾燥drying over anhydrous magnesium sulfate
3. 3
   濃縮Concentrating the solvent under reduced pressure
4. 4
   その他the resulting residue was purified on silica gel column chromatography (C-200; ethyl acetate:hexane=1:19-1:9-1:4)

実験手順

4-Fluorostyrene (3.0 mL), dichlorobis(triphenylphosphine)palladium (870 mg) and potassium carbonate (5.2 g) were added to DMF (70 mL) solution of 4-iodo-2-(4-methoxybenzyloxy)pyridine (4.25 g) and stirred at 100° C. for 19 hours. Saturated brine was added to the reaction liquid, followed by extraction with ethyl acetate and drying over anhydrous magnesium sulfate. Concentrating the solvent under reduced pressure, the resulting residue was purified on silica gel column chromatography (C-200; ethyl acetate:hexane=1:19-1:9-1:4) to provide the title compound (2.55 g, 61%).

出典