反応 #43319

ord-0543ca1c38814e0b8f306d13950ad005

反応方程式

Fc1ccc(CBr)cc1
4-fluorobenzyl bromide
O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCCC2)cc1
4-benzyloxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one
CS(=O)(=O)OCc1ccc(F)nc1
2-fluoro-5-methanesulfonyloxymethylpyridine
O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCCC2)cn1
4-benzyloxy-1-[5-(2-piperidin-1-ylethoxy)pyridin-2-yl]-1H-piridin-2-one
O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCCC2)cn1
4-benzyloxy-1-{5-[2-(1-piperidinyl)ethoxy]pyridin-2-yl}-1H-pyridin-2-one
O=c1cc(OCc2ccc(F)cc2)ccn1-c1ccc(OCCN2CCCCC2)cn1
title compound
O=c1cc(OCc2ccc(F)cc2)ccn1-c1ccc(OCCN2CCCCC2)cn1
4-(4-Fluorobenzyloxy)-1-{5-[2-(1-piperidinyl)-ethoxy]pyridin-2-yl}-1H-pyridin-2-one

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Example 25 was repeated except that 4-benzyloxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one and 2-fluoro-5-methanesulfonyloxymethylpyridine were replaced with 4-benzyloxy-1-[5-(2-piperidin-1-ylethoxy)pyridin-2-yl]-1H-piridin-2-one (Example 20) and 4-fluorobenzyl bromide, to provide the title compound.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07732456B2uspto-grants-2010_06