反応 #43316

ord-f4d25164b2b74b7ebebb66f4dc242b34

反応方程式

CC(O)c1ccc(F)cc1
1-(4-fluorophenyl)ethanol
CC(Oc1cc[nH]c(=O)c1)c1ccc(F)cc1
4-[1-(4-fluorophenyl)ethoxy]-1H-pyridin-2-one
O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCCC2)cn1
( 2 )
O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCCC2)cn1
4-benzyloxy-1-{5-[2-(1-piperidinyl)ethoxy]pyridin-2-yl}-1H-pyridin-2-one
O=c1cc(OCc2ccccc2)cc[nH]1
4-benzyloxy-1H-pyridin-2-one
OCc1ccccc1
benzyl alcohol
CC(Oc1ccn(-c2ccc(OCCN3CCCC3)cc2)c(=O)c1)c1ccc(F)cc1
title compound
CC(Oc1ccn(-c2ccc(OCCN3CCCC3)cc2)c(=O)c1)c1ccc(F)cc1
4-[1-(4-fluorophenyl)ethoxy]-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他as obtained

実験手順

Example 12 was repeated except that 4-[1-(4-fluorophenyl)ethoxy]-1H-pyridin-2-one as obtained by repeating Steps (1) and (2) of Example 1 in which benzyl alcohol was replaced with 1-(4-fluorophenyl)ethanol, was used in place of 4-benzyloxy-1H-pyridin-2-one, to provide the title compound.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07732456B2uspto-grants-2010_06