反応 #43311

反応方程式

4-Benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one

2-(dimethylamino)ethanol

triphenylphosphine

diethyl azodicarboxylate

→

title compound

収率 66.6%

4-benzyloxy-1-{4-[2-(dimethylamino)ethoxy]phenyl}-1H-pyridin-2-one

収率 66.6%

溶媒

THF

反応条件

後処理

1. 1
   濃縮Concentrating
2. 2
   その他the reaction liquid under reduced pressure
3. 3
   その他the resulting residue was purified on silica gel column chromatography (C-300, methanol: chloroform=1:20-1:10)

実験手順

4-Benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one (150 mg, 0.511 mmol), 2-(dimethylamino)ethanol (0.057 mL, 0.562 mmol), triphenylphosphine (269 mg, 1.02 mmols) and diethyl azodicarboxylate (0.163 mL, 1.02 mmols) were stirred overnight in THF (4 mL). Concentrating the reaction liquid under reduced pressure, the resulting residue was purified on silica gel column chromatography (C-300, methanol: chloroform=1:20-1:10) to provide the title compound (124 mg, 60%).

出典